While the line-up looked solid on paper, the road to Bramham Park was famously bumpy.
Shortly after the first announcement, a major logistical swap saw Feeder and Yeah Yeah Yeahs switch days, a move that sent fans scrambling to reorganise their weekend plans.
The bill also faced a string of high-profile cancellations; Audioslave and The Shins both pulled out, while the emo contingent took a hit when From First to Last (featuring a pre-Skrillex Sonny Moore) and Paramore both withdrew due to their lead singers' throat issues.
Despite the dropouts, the weekend was packed with unique moments, such as Flogging Molly pulling double duty by playing sets in both the punk tent and on the main stage.
For those lucky enough to attend, the price of admission for this slice of music history was just £135 for a weekend ticket or £60 for a day pass; figures that feel like a distant memory in today's touring climate.
So, who were some of the big names to perform at Leeds Festival 2006, and where are they now?
13. Pearl Jam (Main Stage)
The grunge legends are currently discussing their 13th studio album. While the full band prepares for new music, frontman Eddie Vedder has announced a solo tour for April 2026. | Getty Images
14. Placebo (Main Stage)
Placebo remain a formidable live force, with 2026 dates already locked in, including a special performance at the Royal Albert Hall for the Teenage Cancer Trust in March. | Getty Images
15. My Chemical Romance (Main Stage)
MCR are the biggest story of 2026, embarking on their The Black Parade 20th Anniversary Tour. They are playing multiple sold-out nights at Wembley Stadium in July 2026, performing the iconic album in its entirety. | Getty Images
16. Primal Scream (Radio 1 Stage)
The band remains active but faced controversy in late 2025, leading to them being dropped from several 2026 festival line-ups over visuals used during their live shows. | Getty Images
17. Dizzee Rascal (Radio 1 Stage)
The grime pioneer is still 'Bonkers,' with a busy 2026 festival schedule already announced, including headlining Summer Fest at the Beach in June and appearing at Victorious later in the summer. | Universal Images Group via Getty
18. The Vines (Radio 1 Stage)
Craig Nicholls has kept the band going sporadically, though they are much less active on the international stage than they were in 2006. They remain a legendary name in garage-rock revival. | Getty Images