While the line-up looked solid on paper, the road to Bramham Park was famously bumpy.
Shortly after the first announcement, a major logistical swap saw Feeder and Yeah Yeah Yeahs switch days, a move that sent fans scrambling to reorganise their weekend plans.
The bill also faced a string of high-profile cancellations; Audioslave and The Shins both pulled out, while the emo contingent took a hit when From First to Last (featuring a pre-Skrillex Sonny Moore) and Paramore both withdrew due to their lead singers' throat issues.
Despite the dropouts, the weekend was packed with unique moments, such as Flogging Molly pulling double duty by playing sets in both the punk tent and on the main stage.
For those lucky enough to attend, the price of admission for this slice of music history was just £135 for a weekend ticket or £60 for a day pass; figures that feel like a distant memory in today's touring climate.
So, who were some of the big names to perform at Leeds Festival 2006, and where are they now?
25. The Rakes (Radio 1 Stage)
22 Grand Job remains a 2006 anthem, but the band officially split in 2009. Unlike many of their peers, they have resisted the urge to reunite so far. | Getty Images
26. The Kooks (Radio 1 Stage)
Luke Pritchard and the band are celebrating 20 years of Inside In/Inside Out with a run of outdoor UK shows in summer 2026, including a date at The Piece Hall in Halifax. | Getty Images
27. Forward Russia (Radio 1 Stage)
The pride of Leeds’ 2006 Dance to the Radio scene, the band has been on hiatus since their brief 2013-2014 reunion. They remain the definitive sound of that Leeds era. | Provided