Marcelo Bielsa’s men travel to champions Liverpool on Saturday evening for their first top-flight match in 16 years.
But do the bookies believe the Whites’ stay in the top-flight will extend into a second season? Scroll and click through the pages to discover each club’s relegation odds:
7. Wolverhampton Wanderers
Odds to be relegated from the Premier League: 33/1 Photo: RUI VIEIRA
8. Leicester City
Odds to be relegated from the Premier League: 33/1 Photo: ANDY RAIN
9. Everton
Odds to be relegated from the Premier League: 22/1 Photo: Clive Brunskill
10. Southampton
Odds to be relegated from the Premier League: 9/1 Photo: Pool
11. West Ham United
Odds to be relegated from the Premier League: 4/1 Photo: ADAM DAVY
12. Sheffield United
Odds to be relegated from the Premier League: 4/1 Photo: Pool