Marcelo Bielsa’s men travel to champions Liverpool on Saturday evening for their first top-flight match in 16 years.
But do the bookies believe the Whites’ stay in the top-flight will extend into a second season? Scroll and click through the pages to discover each club’s relegation odds:
1. Manchester City
Odds to be relegated from the Premier League: 2000/1 Photo: Pool
2. Liverpool
Odds to be relegated from the Premier League: 2000/1 Photo: Laurence Griffiths
3. Manchester United
Odds to be relegated from the Premier League: 1500/1 Photo: MIKE HEWITT
4. Chelsea
Odds to be relegated from the Premier League: 1500/1 Photo: Mike Hewitt
5. Arsenal
Odds to be relegated from the Premier League: 150/1 Photo: Shaun Botterill
6. Tottenham Hotspur
Odds to be relegated from the Premier League: 100/1 Photo: KIRSTY WIGGLESWORTH