The festival is making its return on June 26 from 12pm to 9pm - offering food, drinks and entertainment for the whole family to enjoy.
Celebrating 'everything Leeds , there will be live bands, DJs and a dance act.
The festival is themed around supporting local businesses and entrepreneurs, with the majority of food, drink, music and entertainment on offer originating from Yorkshire.
The festival will be hosted by 212 Cafe & Bar with fresh pints served by Kirkstall Brewery and Magic Rock Brewing and rum cocktails on offer from Black Tears Rum.
A Leeds street food bistro will be on-hand with a unique take on everything from fried chicken to a vegan alternative and Doh' Hut will be bringing handmade doughnut creations for dessert.
Leeds DJ Alex Simmons will be joined by singer Lauren Green to perform the headline set of old school house, disco and dancefloor tunes.
Alex said: "I'm excited to be performing at The Brewery Wharf as part of The Waterfront Festival 2021.
"After a year of DJing over live streams and recording in the studio, I have rediscovered my passion for music and cannot wait to perform to a live audience.
"Post-Covid is such an exciting time for everyone but more so for people working in the leisure and entertainment industry – it's been a long time, and I cannot wait to get back out there!
"On the day, I'll be performing with singer Lauren Green (Lauren G), bringing you the best in old skool house, disco and some dancefloor classics!"
There will also be live music from the Doghouse Derelicts, and DJ sets from Wes Stakes, Hatty Lovehearts, Scott Broadhead, Gina Moretti, Keith Gillot and Wallop Resident DJ's.
Leeds-based dance studio Dance House will perform on the day as well.
Mark Williams, co-owner of Café 212 and one of the Brewery Wharf Festival organisers, said: “It's been a long, challenging year, particularly for the small independent businesses in the area, but we have survived, and we are back bigger and better than before.
"The people who live and work around Brewery Wharf have shown us immense support over the lockdown period; we have had to adapt to survive; however, we have, and now it's our chance to celebrate, give back and put on the party of the year!"
The festival is free to attend and more details can be found on the Facebook page.