Aidan Sezer, the club’s only experienced scrum-half, is ruled out because of injury, alongside forward James Bentley.
In more positive news, winger David Fusitu’a and back-rower James McDonnell could return, but three-quarter Nene Macdonald remains in Australia on paternity leave.
Here’s how Leeds could line up in a game they have to win to keep faint top-six hopes alive.
. Full-back: Luke Hooley
The Super League rookie has had three good games since first-choice full-back Richie Myler suffered a long-term injury. Photo: Ed Sykes/SWpix.com
. Wing: David Fusitu'a
Missed last week's defeat at Huddersfield because of a back injury, but has been named in the initial squad for Saturday. Photo: Ed Sykes/SWpix.com
. Centre:Luis Roberts (no 24)
With Nene Macdonald still in Australia on paternity leave, Roberts is likely to retain his place. Photo: Tony Johnson
. Centre: Harry Newman
Set for his third comeback game following injury, having got through 80 minutes last week. Photo: Allan McKenzie/SWpix.com
. Wing: Ash Handley
Rhinos' top try scorer this term, likely to remain in his specialist role. Photo: Alex Whitehead/SWpix.com
. Stand-off: Rhyse Martin
Morgan Gannon could start at six, but Rhinos might continue with Martin for a second successive game, so they have a more experienced head in the halves. Photo: Ed Sykes/SWpix.com
7. Scrum-half: Jack Sinfield
As the only available specialist half-back in Rhinos' full-time squad, the 18-year-old is set for his eighth career appearance. Photo: Steve Riding
8. Prop: Mikolaj Oledzki
Will be needed to get Rhinos on the front foot against Hull's big pack. Photo: Alex Whitehead/SWpix.com
9. Hooker: Jarrod O'Connor
Set to continue this season's ever-present run. Photo: Tony Johnson
10. Prop: Sam Walters
Was in the second-row last week, but could revert to prop this time. Photo: Paul Currie/SWpix.com
11. Second-row: James McDonnell
Set to make a welcome return after missing last week's game because of a back injury. Photo: Allan McKenzie/SWpix.com
12. Second-row: Morgan Gannon
Gannon made a successful comeback off the bench last week and is an option at stand-off, but starting in the second-row might take some of the pressure off. Photo: Ed Sykes/SWpix.com