Ahead of kick-off, we've taken a look back at the last time the Whites triumphed over the Reds back in 2001 - a Premier League classic that saw David O'Leary's side hang on to claim a precious win at Anfield with a 2-1. Here's where every player in the starting XI - from both sides - is now.
13. Harry Kewell - Leeds United - LW
Kewell retired with Australian side Melbourne Heart. He's now managing Oldham Athletic in the fourth tier on English football. Photo: Pete Norton
14. Patrik Berger - Liverpool - LW
The Czech ace was part of the Reds' double-winning side that season. He finished his career back with his boyhood club, Sparta Prague. Photo: Daniel Kalisz
15. Olivier Dacourt - Leeds United - CM
He went on to leave the Whites in 2003, moving to Italy to join Roma. He won back-to-back titles with Inter between 2006 and 2008. He's now a pundit in France. Photo: SALAH HABIBI
16. Steven Gerrard - Liverpool - CM
After a brief foray into punditry, the Liverpool icon landed his first gig as a manager with Scottish giants Rangers, who are trying to break Celtic's stranglehold on the Premiership. Photo: Pool
17. David Batty - Leeds United - CM
Batty hasn't taken on a coaching or punditry role, but is involved in advertising campaigns for charitable organisations alongside other former pros. Photo: Michael Steele
18. Dietmar Hamann - Liverpool - CM
The following year, Hamann was a World Cup runner-up with Germany. He finished his playing career at MK Dons, and is now a pundit for various media outlets. Photo: FABRICE COFFRINI