Whites head coach Marcelo Bielsa held his pre-match press conference on Thursday lunch-time and provided his latest team news.
Bielsa revealed that some players coming back from injury would play for United's under-23s on Friday and record signing Rodrigo then came through 45 minutes in the victory against Wolves under-23s, scoring a brace.
Bielsa was unable to guarantee when the likes of Kalvin Phillips, Jamie Shackleton and Pascal Struijk would be back.
With that in mind, this is how we think Leeds will start out in their latest visit to the capital.
1. GK - Illan Meslier
All set for what will still be only a 36th league outing for the Whites following his 21st birthday on Tuesday. Photo by Tim Goode - Pool/Getty Images.
2. RB - Luke Ayling
West Ham have tended to play one upfront of late so Leeds seem likely to line up as a back four and Ayling looks set to be at right back. Photo by Catherine Ivill/Getty Images.
3. CB - Liam Cooper
United's captain who will be at the heart of the Whites defence. Photo by Stu Forster/Getty Images.
4. CB - Diego Llorente
Has now played consecutive full games after his early injury woes with the Whites and looks set to be in the back line for a third game in a row. Also an option as a holding midfielder. Photo by Naomi Baker/Getty Images.
5. LB - Gjanni Alioski
On the bench for Saturday's 1-0 loss at home to Aston Villa but replaced the injured Pascal Struijk as Bielsa shuffled his pack and went to left back so might now start there against the Hammers. Photo by JON SUPER/POOL/AFP via Getty Images.
6. CDM - Mateusz Klich
Went into the holding midfield role after Struijk came off injured against Villa and if Struijk does not make it Klich could now start there given that Kalvin Phillips and Jamie Shackleton are also still recovering. Photo by Michael Regan/Getty Images.