The Whites will have been buoyed by their dramatic late win against Norwich City last weekend, and could take a step closer to safety if they can secure a win at Molineux - a ground they last claimed victory at back in 2016.
As things stand, Leeds are 16th in the Premier League table and four points clear of the relegation zone, and they'll be looking to continue moving away from the bottom three as they head into the back end of the season.
The last time Leeds took on Wolves, back in October, a dramatic late goal from Whites forward Rodrigo Moreno saw them snatch a stoppage time equaliser, in a game where they heavily dominated in terms of possession and shots taken.
Speaking ahead of Friday night's big game, Leeds goalkeeper Illan Meslier said: “It was a good atmosphere in the changing room (after the win), a good feeling for us. It’s good to be back with a win because it’s been a long time without winning a game.
"I think it’s a good start with the new manager. I think we saw some different things today with the team and, with time, we will be better and better and better.
“We are confident with him and I hope, in the next game, we will win again.”
Take a look at the latest news and transfer stories from the Premier League, as the build-up to the weekend action continues:
1. Cubs owners want Chelsea
The owners of Major League Baseball team the Chicago Cubs have confirmed that they are interested in buying Chelsea FC. The group bid is believed to also include US hedge fund entrepreneur Ken Griffin. (BBC Sport) | Getty Images
2. Barca ponder Neves swoop
Barcelona are said to have joined Man Utd in the race to sign Wolves star Ruben Neves, who is likely to cost around £42m. However, it is unclear whether the Catalan giants would commit to such a pricey purchase, given their current financial struggles. (Mundo Deportivo) | Getty Images
3. Red Devils in for Isak?
Manchester United are the latest club to take an interest in Real Sociedad ace Alexander Isak, according to reports. However, should they look to sign the Sweden international, they’d likely face competition from both Liverpool and Arsenal. (Sport Witness) | AFP via Getty Images
4. Fernandez race hots up
Aston Villa, Everton and Spurs are among a host of sides to be linked with River Plate midfielder Enzo Fernandez. The 21-year-old Argentina international is also said to be on La Liga side Real Madrid’s radar. (Birmingham Mail) | Getty Images
5. Spurs urged to sign Raphinha
Ex-footballer Tim Sherwood has urged Spurs to sign Leeds United star Raphinha, claiming he would be a “low-risk signing” and “great player” for Antonio Conte’s side. Liverpool and Man Utd are also said to be keen on the Brazil star. (The Analysis Show) | AFP via Getty Images
6. Coyle set for new role
Ex-Burnley and Bolton Wanderers boss Owen Coyle looks set to be named the new manager of Scottish League One side Queen’s Park. He’s currently managing Indian side Jamshedpur, but could be set for a return to his home nation. (Fife Courier) | Getty Images