The Whites will have been buoyed by their dramatic late win against Norwich City last weekend, and could take a step closer to safety if they can secure a win at Molineux - a ground they last claimed victory at back in 2016.
As things stand, Leeds are 16th in the Premier League table and four points clear of the relegation zone, and they'll be looking to continue moving away from the bottom three as they head into the back end of the season.
The last time Leeds took on Wolves, back in October, a dramatic late goal from Whites forward Rodrigo Moreno saw them snatch a stoppage time equaliser, in a game where they heavily dominated in terms of possession and shots taken.
Speaking ahead of Friday night's big game, Leeds goalkeeper Illan Meslier said: “It was a good atmosphere in the changing room (after the win), a good feeling for us. It’s good to be back with a win because it’s been a long time without winning a game.
"I think it’s a good start with the new manager. I think we saw some different things today with the team and, with time, we will be better and better and better.
“We are confident with him and I hope, in the next game, we will win again.”
Take a look at the latest news and transfer stories from the Premier League, as the build-up to the weekend action continues:
7. Brighton linked with starlet
Brighton and Norwich City have both been credited with an interest in Accrington Stanley starlet Leslie Adekoya. He’s yet to make his senior debut for the club, but the 17-year-old’s fine appearances for the youth side are said to have attracted some attention.(The 72) | AFP via Getty Images
8. Hammers keen on Arsenal ace
West Ham have been tipped to pursue a move for Arsenal’s £52m striker Alexandre Lacazette. The ex-Lyon star could leave the Gunners upon the expiry of his contract this summer, and the Hammers are said to be ready to offer him a bumper deal. (TeamTalk) | Arsenal FC via Getty Images
9. Magpies chase Nunez
Newcastle United are said to be “ready to put an important figure on the plate” to land Benfica goal-machine Darwen Nunez. The lethal striker scored his 24th goal of the season to help his side knock Ajax out of the Champions League on Tuesday night. (Calcio Mercato) | AFP via Getty Images
10. Could Leeds ‘cut losses’ on Rodrigo?
Barcelona are said to be “convinced” that Leeds United will eventually look to “cut their losses” on forward Rodrigo and be persuaded to sell. The Whites signed the £26m man from Valencia in 2020, but he’s scored just 11 goals in 54 outings. (The Athletic) | Getty Images