The Whites face a mouth-watering clash against their bitter rivals on August 14th, and will be hoping to fare a lot better than they did on their last visit to the Theatre of Dreams, which ended in a 6-2 win for the Reds just before Christmas.
Elsewhere, Marcelo Bielsa’s face a difficult December, with matches against Chelsea, Manchester City, Arsenal, and Liverpool to contend with – but Man United legend Gary Neville is fully focused on that pulsating curtain-raiser.
Neville told Sky Sports news as quoted by The Express: "I just hope that Priti Patel and her ministers, rather than concentrating on sort of booing England players, actually allow fans back in the stadium for that game so we can actually get a proper atmosphere.
"It will be a fantastic game. Leeds United being back in the Premier League last season, they were an absolute joy to watch every single game. Manchester United had a good Premier League season.
"If we can get close to a full house in that particular match it will just be an incredible welcome back to fans in the stadium in terms of capacities. It's something that's much needed.
"We've seen the announcement in the last few days that they're going to be full at Ascot and full at Wimbledon, I've not got any reason to think why Old Trafford shouldn't be full for the first game of the season."
We’ve gathered the best of today’s Premier League speculation below...

1. Albion agree Gonzalez fee
Brighton & Hove Albion have reportedly agreed a club record fee of £25m for Stuttgart forward Nicolas Gonzalez. The Seagulls were desperate for goals last season, and a new striker is there transfer window priority. (Guardian) (Photo by Focke Strangmann - Pool/Getty Images) Photo: Pool

2. Rose joins Watford
Watford have completed the signing of free agent left-back Danny Rose. The 29-cap England international was released by Spurs at the end of last season, and spent some time on loan with the Hornets back in 2009. (Club website) (Photo by Shaun Botterill/Getty Images) Photo: Shaun Botterill

3. Mourinho wants Patricio
Wolves goalkeeper Rui Patricio looks set to leave the Molineux, with Jose Mourinho's Roma set to swoop for the veteran stopper. He's spent three Premier League seasons with the club, since joining from Sporting CP in 2018. (Football Insider) (Photo by David Ramos/Getty Images) Photo: David Ramos

4. Toon keen on Diakhaby
Newcastle United and Leicester City are showing an interest in signing Valencia defender Mouctar Diakhaby this summer. (AS) (Photo by Aitor Alcalde/Getty Images) Photo: Aitor Alcalde

5. Young to snub Burnley
Ashley Young has decided to sign for Aston Villa, rejecting a move to Premier League rivals Burnley. (Mirror) (Photo by Gabriele Maltinti/Getty Images) Photo: Gabriele Maltinti

6. Bryan set for talks
Sheffield United will hold talks with Kean Bryan over his future at the club. Burnley are among the clubs who have been linked with a move for him. (Sheffield Star) (Photo by Gareth Copley/Getty Images) Photo: Gareth Copley

