The Whites face a mouth-watering clash against their bitter rivals on August 14th, and will be hoping to fare a lot better than they did on their last visit to the Theatre of Dreams, which ended in a 6-2 win for the Reds just before Christmas.
Elsewhere, Marcelo Bielsa’s face a difficult December, with matches against Chelsea, Manchester City, Arsenal, and Liverpool to contend with – but Man United legend Gary Neville is fully focused on that pulsating curtain-raiser.
Neville told Sky Sports news as quoted by The Express: "I just hope that Priti Patel and her ministers, rather than concentrating on sort of booing England players, actually allow fans back in the stadium for that game so we can actually get a proper atmosphere.
"It will be a fantastic game. Leeds United being back in the Premier League last season, they were an absolute joy to watch every single game. Manchester United had a good Premier League season.
"If we can get close to a full house in that particular match it will just be an incredible welcome back to fans in the stadium in terms of capacities. It's something that's much needed.
"We've seen the announcement in the last few days that they're going to be full at Ascot and full at Wimbledon, I've not got any reason to think why Old Trafford shouldn't be full for the first game of the season."
We’ve gathered the best of today’s Premier League speculation below...

7. Tavares in demand
Brighton and Southampton have made approaches for Benfica full-back Nuno Tavares, although neither side has submitted a formal offer yet. (Record) (Photo by PATRICIA DE MELO MOREIRA/AFP via Getty Images) Photo: PATRICIA DE MELO MOREIRA

8. Leeds in advanced talks for Miller
Leeds United are interested in signing Birmingham City forward Amari Miller this summer. The Whites have already begun talks with the Championship outfit and discussions are thought to be advanced.(Football Insider) (Photo by Charlotte Tattersall/Getty Images) Photo: Charlotte Tattersall

9. Leeds willing to spend big on Traore
Leeds United are willing to break their transfer record to sign Wolves wide man Adama Traore this summer. A £40 million bid could be enough to secure his services. (Eurosport) (Photo by Catherine Ivill/Getty Images) Photo: Catherine Ivill

