Farke will likely select Willy Gnonto in place of Dan James who limped off at the Riverside Stadium on Tuesday night with a hamstring problem.
Gnonto has struggled with an ankle issue of his own lately but was able to start against Luton Town last Saturday and came off the bench versus Middlesbrough in midweek.
United's boss has tended to rotate mainly when injuries have forced his hand, therefore there is a strong chance the other 10 starts from Tuesday night will remain in place when the teamsheets are released on Saturday morning.
Two players who will not feature at Elland Road this weekend are Joe Rothwell (calf) and Pascal Struijk (foot). The former is out for the next three games, while the result of a scan on Struijk's injured foot will determine whether his season is over or not.
Here is the YEP's predicted XI vs the Deepdale club.
1. GK: Karl Darlow
Described as 'solid' by Farke following his Luton display and worthy of a clean sheet at the Riverside on Tuesday night, Darlow is a near-certainty to start Leeds' remaining fixtures this season. | Getty Images
2. RB: Jayden Bogle
Another who is among the first names on the teamsheet for the rest of the campaign, Bogle is undisputed first-choice at right-back after overcoming an early season blip and looks to have turned into a really astute signing. Photo: George Wood
3. CB: Joe Rodon
Leeds' rock at the back, rarely ever injured and rarely ever dips below a seven-out-of-ten performance. Photo: George Wood
4. CB: Ethan Ampadu
Strong partnership alongside central defensive partner Joe Rodon, only strengthened by the relationship he has with international teammate Darlow behind him in the Leeds goal. For as long as Struijk is out, the skipper is more than capable of deputising. Photo: Michael Regan
5. LB: Junior Firpo
A certified threat this season with double figures for goal contributions, Firpo was involved in the build-up for Leeds' only awarded strike at Middlesbrough. Photo: Stu Forster
6. CM: Ilia Gruev
For as long as Ampadu is at centre-half, Gruev will fill in as the 'deep six' in Farke's system. A decent enough display in midweek, which Leeds required given the listing form of midfield partner Ao Tanaka. | Getty Images