The Whites slumped to a 2-0 defeat against Brighton last weekend, slipping out of the top half as a consequence of that result, but will be hoping to bounce back against Spurs.
As for the north Londoners, they will know that anything other than a win will seriously dent their hopes of a top four finish and Champions League football next term.
Speaking ahead of the crucial game, Leeds boss Marcelo Bielsa admitted that he had a tough decision to make over who will start at the heart of defence.
He said: "Pascal [Struijk] and Llorente have shown that they can live up to the level that the previous people who have played in this position were playing at.
"But as you well know, there are other factors that are taken into consideration when you look at each game.
"And in any case what I always consider is what is best for the team and what is best for each player that participates because there is nothing more important than to look at the participation of each player.
"Every time you take a decision you don't only think about the good of the team, you consider each individual.
"Being a starter doesn't just generate a hierarchy within the players available so it doesn't favour any player to be in a starting position if they are not in conditions to respond at their best level."
We've gathered the best of the rest of today's Premier League transfer speculation below...

. LEEDS, ENGLAND - FEBRUARY 23: A general view inside the stadium as players of Leeds United warm up prior to the Premier League match between Leeds United and Southampton at Elland Road on February 23, 2021 in Leeds, England. Sporting stadiums around the UK remain under strict restrictions due to the Coronavirus Pandemic as Government social distancing laws prohibit fans inside venues resulting in games being played behind closed doors. (Photo by Gareth Copley/Getty Images)
Leeds United at Elland Road. (Photo by Gareth Copley/Getty Images) Photo: Gareth Copley

. Villa want McNeil
Aston Villa are preparing a £15 million bid for Burnley winger Dwight McNeil. (Football Insider) (Photo by Gareth Copley/Getty Images) Photo: Gareth Copley

1. Villa want McNeil
Aston Villa are preparing a £15 million bid for Burnley winger Dwight McNeil. (Football Insider) (Photo by Gareth Copley/Getty Images) Photo: Gareth Copley

2. Pep plots Bissouma raid
Manchester City are being linked with a move for Yves Bissouma at Premier League rivals Brighton. (Daily Star) (Photo by Mike Hewitt/Getty Images) Photo: Mike Hewitt

3. Clarets cool off Wilson interest
Burnley have cooled their interest in Liverpool winger Harry Wilson and are not expected to pursue his signature in the summer. (The Athletic) (Photo by Ross Kinnaird/Getty Images) Photo: Ross Kinnaird

4. Berge price drops
Arsenal and Everton are considering bids for Sheffield United midfielder Sander Berge as his release clause has reduced to £35million. (Sky Sports) (Photo by OLI SCARFF/POOL/AFP via Getty Images) Photo: OLI SCARFF

5. Redknapp urges Gunners to sign Ryan
Mat Ryan would be a “very good” pick up for Arsenal as a permanent signing from Brighton & Hove Albion, according to Harry Redknapp. (The World Game) (Photo by Bryn Lennon/Getty Images) Photo: Bryn Lennon

6. Ajer tipped for Toon switch
Celtic defender Kristoffer Ajer will ‘end up at Newcastle United’ if he is going to leave the Scottish Premiership giants during the summer transfer window, former Norway international Vidar Riseth. (Daily Record) (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol