He will allow cameras into his life as he looks at how the condition is impacting him and will meet experts leading research into potential treatments.
The one-off, 60-minute special will see Paxman speak to the president of Parkinson's UK, Jane Asher, attend an English National Ballet therapy dance class and learn to play bowls.
He will also observe a brain dissection.
The special comes from Docsville Studios, Altitude Factual and Expanded Media.
Shortly after moving to London in 1977, he transferred from Tonight to investigative flagship programme Panorama, before stints on the Six O'Clock News and BBC One's Breakfast Time.
He became a presenter of Newsnight in 1989, a position he would hold until June 2014 during which time he interviewed high-profile figures from politics and culture.
Paxman has also presented University Challenge since 1994, making him the longest-serving current quizmaster on UK TV.
He revealed in May 2021 he was being treated for Parkinson's disease but said his symptoms were "currently mild".
In a statement at the time, he said: “I plan to continue broadcasting and writing for as long as they’ll have me and have written about my diagnosis in more detail for the June issue of the marvellous Saga Magazine.”