Coyle, who was appointed at the end of last season, has paid the price for Sunday’s surprise 24-22 defeat by Oxford, which leaves Hunslet outside the top four.
“Hunslet RLFC can today announce that head coach James Coyle has left the club with immediate effect,” a statement said.
“The club will make a statement in due course once a decision regarding a future appointment has been made.”
The axing comes just six days after Doncaster parted company with Gary Thornton.