Marcelo Bielsa' s Whites were blitzed 6-2 in the corresponding fixture last December but proved a different proposition in April's Elland Road rematch which ended in a goalless draw.
Diego Llorente (muscle) is the only Leeds injury and this is how we think the Whites will line up in the Saturday lunchtime showdown at Old Trafford.
Leeds are heading for Manchester following a quickfire double contracts boost.
Head coach Bielsa signed a new one-year deal with the club on Thursday, running to the end of the 2021-22 campaign.
Goalkeeper Illan Meslier has also since put pen to paper on a new five-year deal.
7. Mateusz Klich (CM)
The Poland international has looked in decent nick during pre-season and looks pretty sure to start in centre midfield, although Dallas is another option there if Firpo starts at left back. Picture by Bruce Rollinson.
8. Raphinha (RW)
The mesmeric Brazilian winger looked to be coming to the boil at just the right time with a promising performance against Villarreal. Seems certain to start out wide and highly likely on the right flank. Photo by Tony Marshall/Getty Images.
9. Jack Harrison (LW)
After three seasons on loan from Manchester City, Harrison is finally Leeds United's player and appears a certainty to start, probably on the left. Might well swap sides with Raphinha at some point. Photo by Lewis Storey/Getty Images.
10. Rodrigo (ACM)
With a full pre-season behind him, United's record signing will surely start as United's no 10 although Tyler Roberts is another option there and replaced Rodrigo at half-time in the friendly against Villarreal. Photo by Tony Marshall/Getty Images.
11. Patrick Bamford (ST)
The quest to kick on again from last season's stellar haul of 17 goals and seven assists starts here. Bamford looked superb against Villarreal and the Whites no 9 will naturally lead the line upfront. Picture by Bruce Rollinson.