Marcelo Bielsa will still be without influential midfielder Kalvin Phillips for the top flight meeting in West Yorkshire.
Record signing Rodrigo is also still sidelined while long-term absentee Robin Koch is due to return to training next week.
Mateusz Klich is a doubt for the clash after being forced off with a hip issue against Southampton in midweek and will require a fitness test.
Gaetano Berardi has recently stepped up his rehab after a torn ACL last summer with Adam Forshaw (hip) out.
Diego Llorente provided a boost for Bielsa against the Saints but the Argentine has a decision to make over his inclusion against Villa.
Dean Smith opts for one up front in attack, which will more than likely see Leeds revert to a 4-1-4-1 formation - will Llorente or Pascal Struijk be deployed as the sitting defensive midfielder?
With Klich potentially absent, here's how we see Leeds lining up in LS11 this weekend...
2. RWB - Ayling
Always a threat from right-back. Much better at home in his natural position.
3. CB/CDM
What Bielsa opts to do with Llorente will be intriguing. A return to a back three made sense in midweek, but you feel he may be reluctant to put him in a demanding midfield role so soon.
5. LWB - Alioski
With Klich potentially out, Gjanni would be favourite to come in with Dallas moving into midfield. It will all rest with whether the Poland international passes a fitness test.
6. CDM/CB - Struijk
Would be preferable to play him alongside Cooper - hard to know whether Bielsa will allow Llorente a midfield role as he returns to full fitness. If not, a move forward may be required.