Losing by four goals in any game is always a kick in the teeth, but to lose to such a bitter rival by such a large margin will have really stuck in the craw for many Whites supporters.
Prior to that meeting in December, it had been quite some time since the two sides had met, with the most recent clash coming in the League Cup in 2011 – a match which the Reds won 3-0.
In fact, to find Leeds’ last win against Man United, you have to go back to the year previous, when a Jermaine Beckford strike settled a famous FA Cup tie in their favour.
But this is a rivalry that stretches back way beyond the past decade or so.
The first official meeting between Leeds and Man United came in January 1923, with the game ending in a stalemate.
In the years since, the sides have met on 108 other occasions, but who has had the better of the clashes, and how does it rank in terms of ferocity compared to some of the biggest rivalries in English football?
Paddy Power have ran the numbers, comparing win percentages from derby clashes between every Premier League club and their most fierce foes to determine which clashes truly are the most competitive.
Click and scroll through the pages below to read our countdown...
. LIVERPOOL, ENGLAND - FEBRUARY 07: A general view of the Nike Flight yellow match ball placed on a training cone during the Premier League match between Liverpool and Manchester City at Anfield on February 07, 2021 in Liverpool, England. Sporting stadiums around the UK remain under strict restrictions due to the Coronavirus Pandemic as Government social distancing laws prohibit fans inside venues resulting in games being played behind closed doors (Photo by Jon Super - Pool/Getty Images)
Premier League match ball. (Photo by Jon Super - Pool/Getty Images) Photo: Pool
. Fulham vs Chelsea
Matches: 86
Fulham win %: 12.8%
Chelsea win : 57%
Win % difference: 44.2%
(Photo by Carl Recine - Pool/Getty Images) Photo: Pool
. Southampton vs Portsmouth
Matches: 71
Southampton win %: 49.3%
Portsmouth win %: 29.6%
Win % difference: 19.7%
(Photo by ANDY RAIN/POOL/AFP via Getty Images) Photo: ANDY RAIN
1. Fulham vs Chelsea
Matches: 86
Fulham win %: 12.8%
Chelsea win : 57%
Win % difference: 44.2%
(Photo by Carl Recine - Pool/Getty Images) Photo: Pool
2. Southampton vs Portsmouth
Matches: 71
Southampton win %: 49.3%
Portsmouth win %: 29.6%
Win % difference: 19.7%
(Photo by ANDY RAIN/POOL/AFP via Getty Images) Photo: ANDY RAIN
3. Leeds United vs Manchester United
Matches: 108
Leeds win %: 24.1%
Man United win %: 43.5%
Win % difference: 19.4%
(Photo by Adam Davy - Pool/Getty Images) Photo: Pool
4. Aston Villa vs Birmingham City
Matches: 128
Aston Villa win %: 44.5%
Birmingham win %: 29.7%
Win % difference: 14.8%
(Photo by Clive Mason/Getty Images) Photo: Clive Mason
5. Liverpool vs Everton
Matches: 288
Liverpool win %: 42%
Everton win %: 28.5%
Win % difference: 13.5%
(Photo by JON SUPER/POOL/AFP via Getty Images) Photo: JON SUPER
6. Manchester United vs Manchester City
Matches: 184
Man United win %: 41.3%
Man City win %: 29.9%
Win % difference: 11.4%
(Photo by Michael Regan/Getty Images) Photo: Michael Regan