Their meeting at Elland Road will be the first time the two teams have met in the Premier League since 2004, but there have been other clashes in the years since.
The most memorable for Leeds fans is undoubtedly the 1-0 FA Cup upset at Old Trafford in 2010, with Jermaine Beckford scoring the decisive goal.
Click and scroll through to see what the Whites’ lineup from that day are up to now:
Click and scroll through to see what the Whites’ lineup from that day are up to now:
2 / 2