The Whites would move level on points with 10th-placed Arsenal with a win over the Blues, and could also bring to an end a run of two straight defeats.
They face a tough task, however, with Chelsea still yet to lose a game under new manager Thomas Tuchel.
A win for the Blues would move them level on points with Leicester City in third.
With that in mind, Bielsa has shuffled his pack a little from Monday night’s 2-0 defeat to West Ham.
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Pascal Struijk comes back into the side to partner Diego Llorente at the heart of defence, with Liam Cooper dropping out.
Ezgjan Alioski returns at left-back, allowing Stuart Dallas to push back into midfield. Mateusz Klich is on the bench.
Jack Harrison is also given a run out – Helder Costa has to make do with a spot among the substitutes.
Summer signing Robin Koch is back in the match day squad as well.
Here are some of the best reactions from fans on Twitter:
@LeeTheEel_ tweeted: “Probably the weirdest XI we've had all season. Just win”.
@adam2986 tweeted: “Obviously didn't learn from watching alioski wandering like a lost sheep against them last time...and don't even understand Roberts starting. Hey ho”
@J1nsu5590 tweeted: “What is this?”
@wanny_8 tweeted: “Painful”
@samlufcc tweeted: “Wait what? This whole squad baffles me”
@hrbenn tweeted: “How we’ve still got Roberts playing ahead of Rodrigo amazes me”.
@dgreenwood87 tweeted: “Getting beyond laughable now”