The Whites squad is short on experience of football in the country's top flight but six players have experience of playing there, with some very early on in their careers.
Lee Sobot looks at who, and when.
1. Pablo Hernandez - 57 games
'El Mago' leads the way in terms of the United players with Premier League experience with 57 outings for Swansea and five goals between September 2012 and May 2014. Photo by Stu Forster/Getty Images.
2. Adam Forshaw - 35 games
Forshaw is United's second most experienced player in terms of Premier League football with 35 outings, 34 for Middlesbrough and one with Everton - back in April 2011. Photo by OLI SCARFF/AFP via Getty Images.
3. Patrick Bamford - 27 games
Signed by Chelsea aged 18 and whilst he never played for the Blues, Bamford has had 27 Premier outings over four different clubs - Crystal Palace, Burnley, Norwich City and Middlesbrough - scoring once for the latter. Photo by Matthew Lewis/Getty Images.
4. Helder Costa - 25 games
Costa has had 25 Premier League outings - all with Wolves in the 2018-19 campaign for whom he netted once in the top flight . Photo by Ross Kinnaird/Getty Images