As Meslier came off injured at Molineux, the thought of trudging through the final games of the Whites' fight for survival without one of the club's most consistent performers was frightening indeed.
It was fortunate that Kristoffer Klaesson filled in impressively on his Premier League debut to help United cling on for a massive 3-2 win against Wolves, but with a stroke of good luck of the kind Leeds have mostly gone without this term, Meslier came through his injury - a huge bruise - quickly enough to return for the next league game.
Leeds' defence has, for large parts of this season, been a little rocky. On Saturday at Vicarage Road, the Frenchman kept a clean sheet for the first time since November, when Leeds beat Crystal Palace 1-0 at Elland Road.
The Whites suffered a run of a staggering 17 Premier League games without a clean sheet, and no team in the league have conceded more than the 68 goals that the Whites have shipped.
But it could have been much more without the contribution of the United's number 1, who tops the Premier League goalkeeping charts with a whopping 118 saves.
At just 22 years old, Meslier is shaping up to be one of the brightest goalkeeping talents of the future.
But how does he measure up against the other shot-stoppers in the league? Here, we rank from bottom to top every first-choice goalkeeper by the number of saves per million the club paid in transfer fee.
Leeds' defence has, for large parts of this season, been a little rocky. On Saturday at Vicarage Road, the Frenchman kept a clean sheet for the first time since November, when Leeds beat Crystal Palace 1-0 at Elland Road.
7. David de Gea, Manchester United - 4.84 saves per million
Saves: 109 Transfer fee: £22.5m Photo: Naomi Baker
8. Emiliano Martínez, Aston Villa - 4.85 saves per million
Saves: 76 Transfer fee: £15.66m Photo: George Wood
9. Hugo Lloris, Tottenham Hotspur - 7.5 saves per million
Saves: 85 Transfer fee: £11.34m Photo: Stu Forster
10. Łukasz Fabiański, West Ham United - 12.78 saves per million
Saves: 92 Transfer fee: £7.2m Photo: Steve Bardens
11. Martin Dúbravka, Newcastle United - 13.89 saves per million
Saves: 50 Transfer fee: £3.6m Photo: Stu Forster
12. José Sá, Wolverhampton Wanderers - 14.72 saves per million
Saves: 106 Transfer fee: £7.2m Photo: Naomi Baker