They will be hoping to bounce back after their midweek defeat to Liverpool, while Antonio Conte’s side head into the match off the back of a disappointing loss against Burnley.
The Whites remain without Patrick Bamford, Kalvin Phillips and Liam Cooper, however Diego Llorente and Robin Koch may return to the squad.
Spurs could be without January signing Rodrigo Bentancur, while Oliver Skipp and Japhet Tanganga are likely to be absent.
If Leeds can cause an upset then they could overtake Brentford in the Premier League table.
Here are the best of today’s transfer rumours...
1. Magpies handed boost in defender pursuit
Newcastle United have been handed a boost in their bid to sign Lyon centre-back, Jason Denayer, with the French club struggling to tie him down to a new contract. The 26-year-old has made 14 league appearances this season, scoring three times. (TEAMtalk) Photo: Eurasia Sport Images
2. West Ham rival Everton for Robins teen
West Ham and Everton are reportedly among a number of clubs chasing Bristol City starlet Alex Scott. The 18-year-old has scored three goals and assisted another two in 27 league appearances this season. (Daily Mail) Photo: Alex Davidson
3. Red Devils target Chelsea star
Manchester United are eager to sign Chelsea's Antonio Rudiger when his contract expires this summer. The 28-year-old has been rumoured to be looking to depart Stamford Bridge at the end of the season. (Mirror) Photo: Francois Nel
4. Hammers eye Tottenham defender
West Ham are one of a number of clubs targeting Tottenham centre-back Cameron Carter-Vickers this summer. The 24-year-old has impressed whilst on loan with Celtic this season. (TEAMtalk) Photo: Mark Runnacles
5. Leicester to open talks with midfield ace
Leicester City are preparing to open contract talks with Wilfred Ndidi, with the likes of Manchester United and Aston Villa keen on signing the Nigerian. His current deal expires in 2024. (Football Insider) Photo: Visionhaus
6. Leeds urged to target Seagulls man
Former Scotland boss Alex McLeish has advised Leeds United to consider replacing Marcelo Bielsa with Brighton head coach Graham Potter. The Whites are currently three points above the relegation zone. (SussexLive) Photo: PAUL ELLIS