Marsch's tenure began with a 1-0 defeat at Leicester City on Saturday lunchtime and Adam Forshaw only made the bench at the King Power Stadium having been forced to miss parts of training during the week.
Forshaw replaced Mateusz Klich as one United's two central midfielders with 20 minutes left but Diego Llorente missed out altogether due to a minor muscle injury, joining Kalvin Phillips, Liam Cooper and Leo Hjelde on the sidelines
But Patrick Bamford returned to the bench against the Foxes as an unused substitute following his recent injury issues and Marsch has revealed that the Whites no 9 will definitely play against the Foxes - but from the bench.
Leeds were dealt a fresh injury blow in the latter stages of the weekend's clash against Leicester as Tyler Roberts ruptured his hamstring after replacing Jack Harrison as United's third and final change.
Roberts is now facing around three months out.
Marsch provided the latest team news at Wednesday afternoon's press conference and this is how we think Leeds will line up against Steven Gerrard's side.
7. CM - Stuart Dallas
Dallas had his latest shift at right back against Leicester and Marsch may opt to play him there again and Ayling at centre-back but there must be a strong chance of the player of the year now moving into midfield as part of a 4-2-2-2. Photo by Michael Regan/Getty Images.
8. RW - Raphinha
United's Brazilian star has been well below his usual brilliant best for several weeks now and Raphinha was even benched by Marcelo Bielsa but Marsch will surely be keen to get the best out of the Selecao star on the right wing. Photo by George Wood/Getty Images.
9. LW - Jack Harrison
It seems pretty clear that Marsch and Harrison have a strong connection and Harrison has spoken this week about the new boss looking to play him in a different role, essentially more central in the 4-2-2-2 it seems.Photo by George Wood/Getty Images.
10. ST - Rodrigo
Fresh from his 31st birthday on Sunday, United's record signing looks a fairly certain starter as part of the front line in a 4-2-2-2/4-3-2-1, assuming Marsch opts for the same system as deployed against Leicester. Photo by Laurence Griffiths/Getty Images.
11. ST - Dan James
There's always the chance of James reverting to the left wing but he had another stint upfront against Leicester and that looks the likely starting point against Villa until Bamford reappears from the bench although starting Joe Gelhardt is another obvious option. Photo by Laurence Griffiths/Getty Images.