Head coach Marcelo Bielsa has already confirmed that playmaker Pablo Hernandez will miss another two weeks with his groin injury and the YEP's Lee Sobot takes a look at a predicted Whites starting XI for the high noon showdown at Bramall Lane.
7. Mateusz Klich (CM)
Has started life in the Premier League with an almighty bang and already has two goals and an assist so a banker for the central midfield role. Photo by Carl Recine - Pool/Getty Images.
8. Helder Costa (RW)
Another who has started the top-flight campaign in very impressive fashion with two goals and an assist. Arguably United's best player so far. Becoming a real menace on the right flank. Photo by Laurence Griffiths/Getty Images
9. Rodrigo (ACM)
With Pablo Hernandez injured it's either Tyler Roberts or record signing Rodrigo in the no 10 role. It didn't happen for Rodrigo there against Fulham but the Spanish international might again edge out Roberts. Photo by Laurence Griffiths/Getty Images.
10. Jack Harrison (LW)
Leeds will have to do without him next weekend against Manchester City due to the terms of his loan move but another player who is thriving and will be seeking more joy on the left wing. Photo by Laurence Griffiths/Getty Images.
11. Patrick Bamford (ST)
Can he cut it as a Premier League striker? Two goals, an assist and two very strong performances against Liverpool and Fulham tells you of course he can. All set to seek a third goal in three in the no 9 role. Photo by Oli Scarff - Pool/Getty Images