Saints and the Whites will each be without key players for this weekend's sell-out in North London, across several different areas of the pitch.
While some players are in with a chance of making the bench at Wembley, others are ruled out indefinitely and will be forced to watch their teammates from the stands, alongside the 90,000-or-so spectators packed into the national stadium.
Here is a breakdown of the injuries and doubts on either side of the red and white divide ahead of this weekend's clash.
7. Patrick Bamford - (knee)
Bamford remains a doubt for Farke's squad due to his absence over the past month. The striker has not featured since the 4-3 win over Middlesbrough in late April and will take some time to get back up to speed. If he is to play a part this weekend, he will need to have been back in training this week, preferably for the full duration. At this stage, it looks unlikely he will start ahead of Joel Piroe and Georginio Rutter, or even make the bench. | Getty Images