The Lions visit Elland Road for the second time this calendar year but will likely face a very different proposition to the one they met a matter of weeks ago.
Farke made 10 changes to the lineup which failed to score against the fellow Championship side in the FA Cup and paid dearly for it as the team lacked rhythm and cohesion, allowing Millwall to capitalise and progress to the next round.
Goalkeeper Liam Roberts kept a clean sheet last time out at Elland Road but will play no part on this occasion as he serves a six-match ban for a dangerous challenge on Crystal Palace's Jean-Philippe Mateta, which also took place in the FA Cup.
Leeds are unlikely to make too many changes despite losing out at Portsmouth last Saturday. Farke is pleased the team has been able to get three full nights rest after the Fratton Park disappointment, therefore amendments to the starting lineup are likely to be few and far between.
That said, the likes of Ilia Gruev and Brenden Aaronson have come in for scrutiny on social media, which may prompt Farke to consider his options in midfield on Wednesday evening.
Here's how we expect Leeds to start against Millwall.
7. CM: Ao Tanaka
Another whose performance dropped below its usual level during the early kick-off but it's still difficult to see Farke preferring Joe Rothwell and Ilia Gruev to the Japan international in the No. 6/8 role. Photo: George Wood
8. RW: Dan James
A deserved winner of the Championship's Player of the Month award for February, Leeds could do with James rediscovering his scoring touch at Elland Road on Wednesday. | Martin Rickett/PA Wire
9. LW: Manor Solomon
Calls for Largie Ramazani's recall to the starting lineup have become louder in recent weeks but Solomon probably has enough credit in the bank to maintain his spot in the XI. That said, another blank at home to Millwall could lead to a change at QPR this weekend. | Getty Images
10. AM: Brenden Aaronson
Perhaps the most contentious pick in Farke's starting XI right now, Aaronson's goal contributions have dried up of late and calls for him to be replaced in the No. 10 role by Willy Gnonto have become more vociferous. Farke likes his work-rate, natural stamina and energy off-the-ball which probably keeps him in the lineup, but if there was an alternative out-and-out 10, we might've seen him dropped to the bench by now. | Ben Roberts Photo Photo: Ben Roberts Photo
11. ST: Joel Piroe
The Dutchman's miss at Fratton Park was an incident he won't want to see again but his goalscoring form, particularly at Elland Road, suggests he will find his shooting boots sooner rather than later. | Danny Lawson/PA Wire