The Whites welcome their arch rivals to Elland Road as the two clubs come to blows for a second time this season.
Leeds earned promotion last summer after 16 years away from the top flight to set up a meeting with the Old Trafford outfit on level terms once again.
The Red Devils will travel across the Pennines to renew rivalries with their old foe as Ole Gunnar Solskjaer leads out his team as a head coach for the first time in LS11.
Bielsa's men enter the clash off the back of two strong results - a win over runaway leaders Manchester City and a draw with reigning champions Liverpool.
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Their next challenge is to topple a side who have won five games on the bounce in league action - amid an afternoon fuelled by more emotion than normal.
"We always try to play in the same manner," Bielsa said ahead of kick-off.
"When we play at our best it is because we manage to impose or put in play the resources that are best suited to us.
"We always have the same objective and always try to reach that objective in the same manner. When we manage to impose them this is when we play well."
Asked about what he had learned from the season so far, Bielsa added: "When you compete you always learn.
"You can see there are problems that we weren't able to solve and you make efforts to solve those things which you weren't able to.
"The Premier League has a characteristic that every game has importance and weight. To evaluate this season with six games left would be not be smart on my part."