The Whites were beaten 1-0 thanks to a second half goal from Harvey Barnes, but they created a host of chances themselves that they just couldn't convert.
Raphinha came closest with an opportunity from a couple of yards out that Kasper Schmeichel somehow kept out.
Marsch was handed more misfortune late in the game as his final substitute, Tyler Roberts, suffered an injury and was essentially a spectator as he limped around the pitch.
Leeds could be caught by Burnley, who currently head the three teams in the drop zone, this evening if the Clarets manage to pull off a shock win over Chelsea. Everton, the side directly below the Whites, visit Spurs on Monday night.