Marcelo Bielsa opted to make a tactical switch last time out in the 1-0 defeat to Wolverhampton Wanderers.
Leeds switched to what was essentially a 4-4-1-1 formation amid the absence of a number of key first team players due to injuries.
Jamie Shackleton and Mateusz Klich shared the workload in midfield with Kalvin Phillips missing while Tyler Roberts started in a bid to bring more creativity behind striker Patrick Bamford.
This move saw Gjanni Alioski drop to the bench as Stuart Dallas dropped to left-back.
Diego Llorente returned to Bielsa's squad at Molineux in a timely boost but Rodrigo and Ian Poveda remain absent in the treatment room.
Long-term absentees Robin Koch and Adam Forshaw remain sidelined while Gaetano Berardi continues rehab after stepping up his return from a torn ACL last July.
Here's how we expect Leeds to line-up against the Saints tonight, with Bielsa sticking to his tactical switch for a second straight game:
1. GK - Meslier
Had the worst stroke of luck imaginable at Wolves on Friday - has been more than solid this season.
2. RB - Ayling
Much better in his natural position. Better to keep him here, with what he adds in attack.
3. CB - Struijk
Another who is far better at home in his natural place. Has struck up a strong partnership with Liam Cooper in recent months.
4. CB - Cooper
Had an up and down day at Wolves last time out. Brilliant at the back but missed a trio of chances. Impressive recently.
5. LB - Dallas
Shifted from midfield back into defence. He adds a lot at wing-back when Leeds dominate the ball.
6. CM - Shackleton
An outing in midfield at Wolves, as he shared the defensive midfield workload alongside Klich in more of a tandem partnership. This worked better as a fix without Phillips.