The Whites are set to renew rivalries with their old foe in West Yorkshire for the first time since their return to the top flight on Sunday afternoon.
There will be no fans in attendance inside LS11 but supporters will be hopeful Leeds can get one over their arch rivals - especially after the 6-2 reverse in December.
Bielsa's men enter the clash off the back of two impressive results against runaway league leaders Manchester City and reigning champions Liverpool.
Ole Gunnar Solskjaer's outfit are up next - and they travel across the Pennines having won five on the bounce in domestic outings.
Leeds will be without club captain Liam Cooper this weekend as he serves a second game of a three-match ban.
Club record signing Rodrigo will continue his absence due to a muscle complaint while star winger Raphinha is also doubtful.
The Brazilian again hasn't trained this weekend amid a thigh problem picked up at the Etihad two weeks ago.
Solskjaer, though, welcomes back defender Eric Bailly back to his squad after he completed Covid-19 protocols this week.
Anthony Martial and Phil Jones remain long-term absentees due to knee issues for the Old Trafford club.
There is a late doubt for the visitors in the form of England forward Marcus Rashford, who hasn't taken part in training this week due to an ongoing foot issue.
Here, we take a look at how Bielsa could line-up his men for the highly-anticipated showdown:
2. Ayling - RWB
Another match where he'll be stand-in captain. Always a threat down the right.
3. Llorente - CB
Enjoying a strong run in the side and has been getting better with each passing game. A goal capped off his recent run against Liverpool.
4. Struijk - CB
Never looks out of place, always at ease - a big compliment for a player who is in his first full season of senior football at Leeds.
6. CDM - Phillips
Another big test for the Yorkshire Pirlo. As ever, one the key cogs in the Bielsa machine.