Both sides are still seeking their first victory of the 2021-22 top-flight campaign and Leeds will be looking to bounce back from Sunday's 3-0 reverse at home to Liverpool.
The Whites lost Diego Llorente to injury against the Reds as part of a contest in which fellow centre-back Pascal Struijk was shown a straight red card, for which he is now serving a three-game ban.
Another centre back, Robin Koch, has also been out injured with a pelvic issue whilst Adam Forshaw missed the Liverpool game with a muscular injury.
Whites head coach Marcelo Bielsa confirmed at Thursday's pre-match press conference that Forshaw, Koch and Llorente would all miss the trip to St James' Park, in addition to the banned Struijk, and this is how we think the Whites will line up.
13. Sub - Cody Drameh
The right back is one of United's brightest young stars and seems fairly sure to be on the bench.
14. Sub - Charlie Cresswell
Talented youngster Cresswell appeared heavily in a Leeds first team training video this week, raising suspicions that he could start at centre-back. But given his inexperience, perhaps the centre-back will have to wait for Tuesday's EFL Cup clash at Fulham.
15. Sub - Mateusz Klich
The Poland international had to settle for being an unused substitute against Liverpool and it might be the bench again for Klich who otherwise could start in centre midfield or at no 10.
16. Sub - Dan James
The summer recruit from Manchester United will surely be starting soon but it might be the bench again for now. Could start on the left or right wing or even at no 10.
17. Sub - Tyler Roberts
The Wales international replaced Rodrigo in the no 10 role at the interval of Sunday's clash against Liverpool but the bench seems likely again given Bielsa's words on Rodrigo at his pre-match press conference.
18. Sub - Crysencio Summerville
It's take your pick from the likes of talented youngsters Crysencio Summerville, Joe Gelhardt or Sam Greenwood for the bench. Perhaps winger Summerville will get the nod although Bielsa has named Liam McCarron in his 18 for the last two league games.