There are also places on the Whites bench for young duo Crysencio Summerville and Sam Greenwood as Joe Gelhardt and Leif Davis drop out of the match day squad.
Raphinha picked up a thigh injury after a hefty challenge from Manchester City's Fernandinho in this month's 2-1 victory at the Etihad and the winger was forced to miss Monday's 1-1 draw at home to Liverpool.
Whites head coach Bielsa then said on Thursday that Leeds were controlling Raphinha's evolution on a daily basis but that the Brazilian still had not trained and the 24-year-old will play no part against the Red Devils.
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Jack Harrison and Helder Costa consequently fill the slots on the wings for Bielsa's unchanged Whites.
Record signing Rodrigo is also still out injured whilst captain Liam Cooper serves the second game of a three-match ban for his sending off in the 2-1 victory at Manchester City.
Adam Forshaw is also out having picked up a muscular injury on his comeback outing for the under-23s.
Marcus Rashford starts for the Red Devils despite having not trained all week due to a foot issue.
Eric Bailly is back on the bench having recovered from Covid-19 but Anthony Martial and Phil Jones remain out injured.
Leeds United: Meslier, Ayling, Llorente, Struijk, Alioski, Phillips, Dallas, Harrison, Costa, Roberts, Bamford. Subs: Casilla, Koch, Berardi, Shackleton, Klich, Summerville, Hernandez, Poveda, Greenwood.
Manchester United: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; James, Fernandes, Rashford; Greenwood. Subs: De Gea, Bailly, Telles, Tuanzebe, Mata, Matic, Pogba, van de Beek, Cavani.
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Thank you Laura Collins