Ahead of the eagerly-awaited clash between the Whites and the Red Devils, chief football writer Graham Smyth runs through the key elements of the Roses derby from LS11.
Competition: Premier League
Venue: Elland Road
Odds: Leeds win 3/1, draw 11/4, Man Utd win 17/20.
Last time at Elland Road: Saturday April 25, 2021 - Leeds United 0-0 Manchester United
Key battle - the midfield: Leeds United cannot afford to leave space in the middle of the pitch the way they did against Everton. Manchester United have players who are well equipped to take full advantage, on the counter attack in particular. Whoever plays in the number eight role and in front of the back four will have a huge job. Expect Adam Forshaw to play.
Man United key man - Bruno Fernandes: Regardless of how good he's been this season compared with how good he can be, he's a real threat to Leeds United. A creative player with vision and the ability to do special things, he can't be given time and space to pick Leeds apart. He's one of a number who could cause big problems if space appears.
Graham Smyth's verdict
It could be one of the best days of Marcelo Bielsa's tenure at Leeds and one of the most enjoyable for Whites fans in decades, or one of the worst. It's hard to see it being anything in between. The atmosphere could help Leeds but they simply cannot perform as they did at Everton. Who knows what Manchester United will produce but they know how to hurt Leeds. Perhaps the best prediction is to expect the unexpected. A 1-0 win with a goal from Adam Forshaw it is, then.