Leeds United v Leicester City team news: Liam Cooper, Pablo Hernandez and Jamie Shackleton all start for Whites
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In line with Premier League and Government guidelines, Rodrigo is now isolating away from the team and the Spaniard misses the clash against the Foxes along with fellow summer recruit Raphinha who has suffered an ankle injury.
Cooper returns from the injury picked up on international duty with Scotland that kept him out of United's recent clashes against Aston Villa and Wolves with the skipper pulling out of the starting line up after the warm-up against Wolves.
Pascal Struijk took Cooper's place at centre-back for the 1-0 loss against Wolves but Struijk was then called to move into the holding midfield role against Villa with Kalvin Phillips out with a shoulder injury.
Luke Ayling instead shifted over from right back to partner Robin Koch at centre-back against Villa with Gjanni Alioski coming into the side at left back as Stuart Dallas moved to the opposite full back position but Alioski now drops to the bench.
Struijk, meanwhile, lasted just 21 minutes of last Friday's 3-0 win at Villa having already been booked and walking a disciplinary tightrope.
Shackleton took his place and now starts from the off with Struijk on the bench.
Centre-back and Spanish international Diego Llorente remains out with a groin issue also picked up on international duty while England international midfielder Phillips is still sidelined with his shoulder injury.
Adam Forshaw also remains a long-term absentee with a hip problem.
Leicester boss Brendan Rodgers has also been forced into making changes and Northern Ireland international centre-back Jonny Evans has failed to make the squad with a back problem meaning he stays on the sidelines along with Belgian international full-back Timothy Castagne who has a hamstring problem.
Evans picked up the injury in last weekend's 1-0 win at Arsenal but Rodgers had hoped the defender would back to face Leeds.
But with Evans missing out and both Caglar Soyuncu and Daniel Amartey also sidelined, Wesley Fofana, Christian Fuchs and James Justin will play in a back three with Wes Morgan only on the bench.
Luke Thomas is also handed his first Premier League start of the campaign as left-wing-back.
There are four changes to the Foxes side that started Thursday's Europa League tie at AEK Athens with Thomas, Harvey Barnes, Papy Mendy and Dennis Praet coming in for Morgan, Hamza Choudhury, James Maddison and Cengiz Under.
Jamie Vardy starts in the lone striker role having recovered from a calf problem and coming through 70 minutes against AEK.
Evans, Timothy Castagne and Maddison all mis out from the side that started last weekend's league clash at Arsenal.
Leeds United: Meslier, Ayling, Koch, Cooper, Dallas, Shackleton, Klich, Costa, Harrison, Hernandez, Bamford. Subs: Casilla, Alioski, Casey, Struijk, Davis, Roberts, Poveda.
Leicester City: Schmeichel, Albrighton, Fofana, Fuchs, Thomas, Justin, Mendy, Praet, Tielemans, Barnes, Vardy. Subs: Ward, Morgan, Choudhury, Maddison, Ünder, Pérez, Iheanacho.
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Thank you Laura Collins