The Whites went into the international still searching for their first league victory of the season, after being held to a 1-1 draw with Burnley, and they'll be eager to get the ball rolling with a big win over the Reds.
When the two sides last faced each other, back in April, Marcelo Bielsa's side held Liverpool to a 1-1 draw, with defender Diego Llorente scoring a dramatic late equaliser.
Meanwhile, as the international break draws to a close, Leeds' U23 side are in Premier League Cup action this evening against Wigan Athletic.
Discussing the difficulties of selecting a side when a number of the players are on youth international duty, head coach Mark Jackson said: “It was always planned (the team selection). We can test some of the Under-18s going into that and see how they're shaping up. A few of the 18s coaches can get a feel for how we work as well, so it's all planned out.
“When we're missing that amount of players [due to international call ups], it gives us time for the lads to kind of work individually and we can do that with some players.
“We can work on areas where they need to get better, work on areas they're good at already and use individualised programs so players can have that time to develop.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
7. Burnley target makes surprise switch elsewhere
Burnley linked winger Thomas Robert has sealed a surprise move from Airdrie to Belgium, joining second-tier side Royal Excel Mouscron. The 21-year-old Frenchman is the son of Newcastle United icon Laurent Robert. (Daily Record) Photo: Nigel Roddis
8. Gunners knock back Elneny bid
Arsenal are believed to have rejected a bid for their £7m midfielder Mohamed Elneny from Galatasaray. The Egypt international could yet leave the club this month, with transfer windows in Turkey and the Czech Republic still open. (Football.London) Photo: Stu Forster
9. Pundit makes bold Phillips claim
Football pundit Gabby Agbonlahor has claimed it is "only a matter of time" until Leeds United sell star midfielder Kalvin Phillips. He's suggested the England international will leave Elland Road to pursue Champions League football. (Football Insider) Photo: George Wood
10. Juve keen on Cavani
Juventus have been linked with a January move for Manchester United striker Edinson Cavani. The veteran forward, who gave up his number seven shirt to new signing Cristiano Ronaldo, is also said to be of interest to Boca Juniors. (Sport Witness) Photo: Michael Regan