The eagerly-anticipated game will see two sides who've had a tricky start to the season battled it out for a much-needed three points, and Marcelo Bielsa's side will be confident of emerging victorious after winning both home and away in the league against Steve Bruce's side in the 2020/21 campaign.
Speaking ahead of the game, Bielsa was to expand on some recent self-criticism, and said: “I am never critical of my job or my labour without explaining why and I did it in the press conference beforehand. The job of a manager is not measured by the quality of the resources that he has but by those resources obtaining the result that we are looking for.
“Normally I don't have problem diagnosing the problems that we suffer but knowing what the problems are doesn't mean having a solution for them or solving them. You start using different resources and it is only good how you manage it if the reality changes.
“I clearly saw that the plan of the opponent (Liverpool) in the last game had a superior effect to the one I proposed for the game. We couldn't neutralise their set pieces, not because we ignored the strength of possibly the best two headers (of the ball) in the Premier League at the moment but because of the way we chose to combat it wasn't effective.”
Take a look at the latest news round-up from the Premier League, as the build-up to the weekend's action continues:
7. Goldson on West Ham's radar
West Ham United have been credited with an interest in Rangers ace Connor Goldson, who could leave the club for nothing ahead of his contract expiring next summer. He joined the Gers from Brighton back in 2018, and won the league title with his side last season. (Sky Sports) Photo: Ian MacNicol
8. Lewandowski open to Reds switch
Bayern Munich superstar Robert Lewandowski is said to be "open" to a move to Liverpool, as he begins to consider the possibility of a new challenge. The Polish striker has played the last decade of his career in the Bundesliga, winning nine league titles. (Fichajes) Photo: David Ramos
9. Whites want Phillips agreement this year
Leeds United are said to have opened talks with Kalvin Phillips over a new, big-money deal, and have reportedly set the goal of reaching an agreement before the end of the year. A host of the Whites' divisional rivals were linked with Phillips over the summer. (Football Insider) Photo: OLI SCARFF
10. Reds ready raid for teenage ace
Liverpool have been tipped to launch a move for RB Salzburg teenager Karim Adeyemi. The talented striker has scored six goals in seven matches for his club so far this season, and made his debut for Germany's senior side earlier n the month. (Mundo Deportivo) Photo: Alexander Hassenstein