The Whites have a nine day gap between top flight fixtures as they make the trip to take on the Hammers in London in front of the Sky Sports Monday Night Football cameras.
Marcelo Bielsa and David Moyes are well underway with their pre-match preparations and will be hoping to welcome back a number of players to their senior squads.
Leeds have several concerns away from their terrible recent capital record, with eight players currently sidelined in the Elland Road treatment room.
West Ham aren't blessed with a fully-fit squad themselves and have immediate concerns over two first-team goalkeepers ahead of kick-off.
Both managers will meet the media later this week to issue an update over any fitness concerns - here, we take a look at the full list of players battling problems ahead the first whistle at the London Stadium.
Leeds United injury concerns
Kalvin Phillips - calf injury
Rodrigo - groin injury
Pascal Struijk - unspecified
Jamie Shackleton - groin injury
Ian Poveda - ankle injury
Robin Koch - knee injury
Gaetano Berardi - ACL injury
Adam Forshaw - hip injury
Marcelo Bielsa will be hoping to receive a boost to his squad ahead of the clash with West Ham in London.
Key midfielder Kalvin Phillips has been a big absence in recent weeks while Rodrigo and Jamie Shackleton have also suffered muscular problems.
Pascal Struijk - as confirmed by Whites playmaker Mateusz Klich - was a forced change due to injury against Aston Villa and no update has been issued over his status as yet.
Winger Ian Poveda, though, returned to the bench for the Under-23s fixture at Crystal Palace on Monday and could feature against Wolves on Friday in a bid to gain match sharpness.
Gaetano Berardi also made his long-awaited comeback from a torn ACL injury against the Eagles as he steps up his rehab while Robin Koch returned to training this week after a long-term knee problem.
Adam Forshaw remains sidelined for the immediate future with a hip problem.
West Ham United injury concerns
Lukasz Fabianski (goalkeeper) - arm injury
Darren Randolph (goalkeeper) - thigh injury
Angelo Ogbonna - ankle injury
Andriy Yarmolenko - knee injury
Ryan Fredericks - groin injury
Arthur Masuaku - knee injury
West Ham have two major worries ahead of the game with the Whites in the form of their first two senior goalkeepers.
Darren Randolph featured against Manchester City last time out but suffered a recurrence of a thigh problem and number one stopper Lukasz Fabianski is battling an arm injury.
Moyes - who sees his side sit fourth in the Premier League - issued an update post-match at the Etihad over the fitness of the pair.
He said: "Darren Randolph is just back from a thigh injury that kept him out for a month or so and he has only been back in training a week or two and he just felt it in the second half again.
"Lukasz picked up a minor injury in training. One of the players accidentally stood on his arm and it caused a problem yesterday. I am hoping he is going to be back [soon], I can't be sure when, we need to see how he recovers and take stock.
"We don't play again until Monday so it gives us a little bit longer to get those players recovered."
The Hammers are also waiting on a further four first team players, but no timescale over their return has yet been made clear ahead of the Leeds fixture.