Tyler Roberts, Adam Forshaw and Jamie Shackleton will all be absent and this is how the Whites are expected to line up at the John Smith's Stadium.
The Whites will go top with a victory with leaders West Brom at home to Swansea City on Sunday lunch-time.
1. Kiko Casilla
Continually impressive and will be looking for an amazing 11th clean sheet for the season so far. Photo by Lewis Storey/Getty Images.
2. Liam Cooper
United's captain who will again be at the heart of the Whites defence. Photo by Gareth Williams/AHPIX LTD.
3. Gaetano Berardi
Looks set to replace the suspended Kalvin Phillips for the only change, either at right back or as part of a back three. Photo by Bruce Rollinson.
4. Ben White
Marcelo Bielsa has already confirmed that the impressive Brighton loanee will move from centre-back to the holding midfield role to replace the banned Phillips. Photo by James Hardisty.
5. Stuart Dallas
Leeds United's Mr Versatile will likely be in centre midfield in the event of a back three or at left back given a back four. Picture by Bruce Rollinson.
6. Jack Harrison
One way or the other the on loan Manchester City ace will be bombing up and down the left flank, either as a left winger in front of a back four or as an all-in left back/left wing back/left midfielder. Photo by Bruce Rollinson.