The international break has given Jesse Marsch some well-needed time to focus the group on the ideas he would like them to play with going forward.
Leeds will additionally be boosted by the availability of Kalvin Phillips, Raphinha, Liam Cooper, Diego Llorente and Illan Meslier after COVID and a freak spate of injuries at Molineux put a significant hole in Marsch's squad.
Patrick Bamford, though, is ruled out for the game, which leaves Marsch with a big question. With Tyler Roberts out until the end of the season while he recovers with a thigh injury, Marsch is left with Rodrigo, Dan James and Joe Gelhardt to choose from as he selects the man to lead the line against Saints on Saturday.
Meanwhile, the bruise Meslier suffered from a collision with Raul Jimenez is not expected to count him out of the tie, but will Marsch favour the chance to build the confidence of Kristoffer Klaesson after the youngster proved himself a very able deputy?
This is how we think Leeds United could line up on Saturday:
7. CM - Mateusz Klich
Faced with the question of who to drop to re-introduce Phillips, Marsch should opt to axe Adam Forshaw so Klich can balance the defensive-minded Phillips. Photo: Stu Forster
8. RW - Raphinha
Raphinha is recovered from COVID and will be raring to make an impact after missing out on the glory of the Wolves game and the chance to feature for Brazil over the international break. Photo: Paul Ellis
9. LW - Jack Harrison
Harrison's hat-trick against West Ham in January shows that he really dazzles when his confidence his high. The winger bagged a goal at Molineux, can he add to his tally at Elland Road on Saturday? Photo: George Wood
10. SS - Rodrigo
A clear favourite of Marsch's at the moment. Off the back of two goals in two games, Rodrigo is a must-start player. Photo: George Wood
11. ST - Dan James
It's decision nobody wants to make. With Patrick Bamford out for six weeks, what to do in his absence will prove a real test for Marsch. He's likely to stick with a tried and tested option on the first go. Photo: Stu Forster