Leeds will face their arch rivals for the fourth time since their Premier League return in Sunday's eagerly-awaited 2pm kick-off in West Yorkshire.
The Red Devils moved back into the Champions League spots via Tuesday night's 2-0 win at home to Brighton whereas Leeds are down in 15th place but de Gea expects a hard test as Roses rivalries are once again renewed.
“I know it’s a massive rivalry between the teams," said De Gea to the Manchester Evening News.
“It’s going to be a tough game, especially away against Leeds – good team, difficult team, different team.
“But we have to win this game as well to be in the top four and hopefully we can go there and win.”