Whites head coach Marcelo Bielsa has made another two changes to his side with Shackleton replaced by Pascal Struijk and Gjanni Alioski coming in for Hernandez and neither Shackleton or Hernandez make the bench.
But with Rodrigo already missing having tested for positive for coronavirus, Alioski and not Tyler Roberts comes into the side as Wales international Roberts stays on the bench.
With Kalvin Phillips and Diego Llorente also both still out injured in addition to long term absentee Adam Forshaw, Struijk looks set to replace Shackleton in the holding midfield role.
Summer recruit Raphinha also returns to the bench having passed a late fitness test following an ankle issue and there are also places amongst the substitutes for young duo centre midfielder Jack Jenkins and centre-back/holding midfielder Oliver Casey.
Palace boss Roy Hodgson has made three changes to his side with last season's top scorer Jordan Ayew returning from self-isolation to start with Michy Batshuayi named on the bench.
Eberechi Eze also comes in for Jeffrey Schlupp while James McArthur returns in the absence of the suspended Luka Milivojević.
Summer signing Jack Butland is also involved for the first time in replacing Stephen Henderson on the bench while James McCarthy and Gary Cahill have also returned to fitness to take their place amongst the substitutes.
With Ayew and Wilfried Zaha starting in a front two, Leeds look likely to go three at the back with skipper Liam Cooper next to Luke Ayling and Robin Koch.
That could mean Alioski and Stuart Dallas playing either side of Struijk with Jack Harrison and Helder Costa ahead of them out wide and with Mateusz Klich behind lone striker Patrick Bamford.
Harrison, though, has also played in a central attacking role before and may be used as a no 10.
Crystal Palace: Guaita, Clyne, Kouyaté, Dann, Van Aanholt, Townsend, McArthur, Riedewald, Eze, Ayew, Zaha. Subs: Butland, Sakho, Cahill, McCarthy, Schlupp, Benteke, Batshuyai.
Leeds United: Meslier, Ayling, Koch, Cooper, Dallas, Struijk, Klich, Costa, Alioski, Harrison, Bamford. Subs: Casilla, Poveda, Roberts, Raphinha, Davis, Jenkins, Casey.
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Thank you Laura Collins