The Whites are two points ahead of the Blades despite Chris Wilder's side earning the same tally over the course of 33 games this season.
Sheffield United were deducted two points which came into effect at the beginning of 2024/25, which causes them to be in second place ahead of Monday night's game.
Both sides have a huge incentive to seize all three points at Bramall Lane, not least for Yorkshire bragging rights. If Leeds are victorious, they will go five points clear of Wilder's men in top spot and perhaps open up an even greater gap to third if Burnley falter at home to Sheffield Wednesday on Friday night.
Sheffield United, on the other hand, know a win will see them move above Leeds into first with only a dozen league games remaining.
Here is the YEP's combined XI, comprised of players from each of the title-chasing sides.
7. CM: Ao Tanaka
A candidate for Championship signing of the season, Tanaka has cool and composure on the ball and tenacity off it. Many have suggested he is a Premier League-standard midfield player and few in this division can match his tempo-dictating, effortlessly-simple play style. Photo: George Wood
8. CM: Gus Hamer
The most attacking of this hypothetical midfield three, Hamer is the player who makes Sheffield United tick. He can create, score goals, gets stuck in and is an excellent all-rounder. So much so, Leeds tested Bramall Lane's resolve with a £13m bid last summer, which was rejected, of course. Photo: Mike Egerton
9. RW: Dan James
There aren't many players in Europe's top leagues who carry a threat on the counter quite like James. The United winger is joint-top of the Championship for big chances created, averages the second-highest xA and xG per 90 of any player in the league and certainly knows where the goal is. A dual threat. | Getty Images
10. LW: Manor Solomon
The Leeds loanee has grown into his role during the second half of the campaign, racking up 14 goal contributions in a relatively short period of time. Like James, he is part of the league's best attack by a distance, is arguably the division's best dribbler and has proven especially difficult to stop. | Gary Oakley/PA Wire
11. ST: Joel Piroe
It's hard to argue there should be a Blades attacker in this front three when Leeds have scored 21 goals more than their South Yorkshire neighbours. Piroe has had a large part to play in that fact, contributing to no fewer than 20 already this season, with 14 goals and six assists to his name. Photo: Ben Roberts Photo