United's Argentine head coach was without the services of nine injured players for last Sunday's FA Cup clash against the Irons, Patrick Bamford finding himself back on the sidelines due to picking up an injury below his hip in training.
That meant Bielsa was without his four main striker options, Bamford out along with Joe Gelhardt (ankle), Rodrigo (heel) and Tyler Roberts (muscle).
Young Sam Greenwood started upfront against the Hammers but was then added to the extensive list after picking up an injury against the Irons.
Kalvin Phillips (hamstring), Liam Cooper (hamstring), Pascal Struijk (foot), Jamie Shackleton (Achilles) and Charlie Cresswell (shoulder) were also missing and Leeds then lost the services of Junior Firpo in the contest following a collision of heads with keeper Illan Meslier.
Firpo revealed after the game that he had felt a bit dizzy and was later feeling fine but there are concussion protocols that must be followed.
In addition to the huge amount of injuries, United's Spanish international defender Diego Llorente is suspended for this weekend's league rematch against the Irons having picked up five bookings, in addition to Roberts who is also banned but injured anyway.
That means there are doubts about 12 players and this is how Leeds could line up in Sunday afternoon's Premier League clash at the London Stadium.
7. CM - Adam Forshaw
A revelation since returning from injury, Forshaw was on the bench last weekend but there's no chance of that this time and he is vital in midfield with Kalvin Phillips out and given the recent injuries to Pascal Struijk and Jamie Shackleton too.
8. ACM - Mateusz Klich
Klich played the full match last weekend and is being kept busy of late but what's new? Now coming up against the Hammers in the league, the Pole looks set for another start in the middle of the park/the no 10 role.
9. RW - Raphinha
It didn't really happen for 'Rapha' after being brought on during the interval of the FA Cup tie but he and Leeds will hope it is a different story this time around and the star Brazilian is crucial to United's attacking threat.
10. LW - Jack Harrison
Harrison and Dan James both squandered good chances when Leeds were 1-0 down on Sunday but Harrison had previously netted his first goal of the season in the win against Burnley and will surely start wide left although Crysencio Summerville is another option.
11. ST - Dan James
After Sunday's loss, Leeds had five strikers out, Sam Greenwood injured at a time when Patrick Bamford, Joe Gelhardt, Rodrigo and Tyler Roberts were also sidelined. The big hope will be that Bamford is back but if no-one returns, it is likely to be James up tops.