The meeting with Ralf Rangnick's side marks the start of a challenging run of fixtures for Leeds.
The Whites have an away trip at Anfield as well as a visit from Tottenham Hotspur to contend with before the end of the month.
Though wins against Burnley and West Ham at the start of 2022 gave Marcelo Bielsa's side a little breathing space from the relegation zone, the fight for survival is far from over.
With Norwich City and Newcastle stringing together half-decent runs of form below them, United must keep up the pace with their bottom-of-the-table rivals to avoid sinking further into the basement.
On Saturday against Everton, the story of Bielsa's season - responding and adapting to a series of injuries to key players - took yet another cruel twist.
Stuart Dallas, whose versatility has been the solution to so many of the Argentine's problems this season, became another problem for Bielsa to solve as he limped off in the eighth minute at Goodison Park.
The Ulsterman was replaced with 18-year-old defender Leo Hjelde, who hobbled off himself at the end of the match after taking a knock.
While the returns of Kalvin Phillips and Liam Cooper are now almost within reach, a fresh pair of injury concerns will give the Whites head coach something new to chew over.
Here, we take a look at those with injury worries ahead of the Manchester United clash before Bielsa gives a more definitive update later this week:
1. Liam Cooper - hamstring
Cooper was given a predicted return date of early March and a picture of the Whites skipper back on the grass at Thorp Arch shared by the club earlier this month is an encouraging sign that he's on track. Photo: Visionhaus
2. Kalvin Phillips - hamstring
Like Cooper, Phillips made a very positive appearance on the club social media channels this month. Recovery going well. Whites fans can't get their talisman back quickly enough - especially since Everton ran riot in the middle of the park on Saturday. Photo: George Wood
3. Patrick Bamford - foot
The Whites number nine just can't catch a break this season. Now that his muscular problems have been fixed, Bamford is suffering from foot pain which is preventing him from running. No return date has yet been offered. Photo: Stu Forster
4. Junior Firpo - thigh
Firpo is likely to be available for the Manchester United clash. In his Aston Villa press conference, Bielsa said the defender might be available for Everton but that caution would be taken with his return as it involved a tendon. Photo: Alex Livesey
5. Sam Greenwood - knee
The young striker had surgery on his knee last month after picking up an injury in the Whites' FA Cup third round defeat to West Ham. On Instagram this week, Greenwood posted a picture of him wearing football boots which can only mean good things for his recovery. Might still be too early for the Reds clash, though. Photo: Lewis Storey
6. Leo Hjelde - knock
The 18-year-old did a superb job of stepping in for Stuart Dallas on just his second Premier League appearance on Saturday. Hjelde went down under a challenge from Seamus Coleman in the dying minutes of the game. An issue with his right leg looked to be causing him considerable discomfort. Photo: Marc Atkins