We asked Yorkshire Evening Post readers that question, and the answers ranged from a number of familiar city-centre frustrations to some more unexpected suggestions.
We've picked out 10 of the answers that came up most often or sparked the most interesting debate.
These are the things that Leeds locals think should be shown the door from the city centre.
7. The one-way traffic system
Leeds' one-way traffic system was singled out by some locals as the one thing they would get rid of. The comments focused on the way traffic moves around the city - and the frustration of navigating some of Leeds' city centre roads. | Gerard Binks
8. Vaping and smoking
Smoking and vaping in busy public spaces also made the list. Readers complained about walking through clouds of cigarette smoke or vapour in crowded parts of the city centre, with some saying they would like tighter restrictions on where people can smoke. | Adobe Stock
9. McDonald's on Briggate
One of Leeds city centre's most recognisable fast-food spots also found itself in the firing line. McDonald's at the bottom of Briggate was named by readers who said it is one thing they would ban from the city centre - a suggestion that is likely to divide opinion among hungry shoppers and late-night visitors. | Google
10. Litter
Rubbish in Leeds city centre was another major frustration for some readers. Several people said they want to see tougher action on litter, with one reader saying they now avoid the centre because of it. | Tony Johnson