Arc Inspirations, whose venues include Banyan Bar and Kitchen, Kith and Kin, The Pit and Trio, is investing £1.2m in a second Manahatta venue.
The new site in Greek Street, formerly occupied by Gourmet Burger Kitchen, is scheduled to open in March.
It will adopt a similar look to the ‘downtown chic’ surroundings of the existing Merrion Street site, but offer a larger food menu for up to 150 diners.
The company said the new bar and restaurant would create 60 full and part-time jobs in the local area.
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Chief executive Martin Wolstencroft said: “I’m extremely proud to be developing the Manahatta brand.
“The prestigious Greek Street location is a fantastic setting and will complement the existing Merrion Street site perfectly.”
He said the investment – announced as Manahatta marks its second anniversary – would allow the creation of brand which could be rolled out to other cities in future.