It happened at about 10.45am on Saturday, May 29 on the M1 northbound, between junctions 42 and 43.
The crash involved three cars – a white Ford Fiesta, a green/blue Ford Fiesta, a grey Mercedes E300 - and a car transporter.
A 54-year-old man, who was driving the white Fiesta, suffered serious injuries.
He was taken to hospital in Leeds
Anyone who witnessed the collision or has any information including dashcam footage is asked to come forward and speak to the police via 101 quoting reference number 13210268177.