The M62 carriageway near Leeds was fully closed by the emergency services following a serious crash.
The M62 westbound was closed between J31 for Normanton and J30 for Rothwell.
Drivers were warned to avoid the area by Highways England.
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Traffic officers and the air ambulance are currently on the scene.
West Yorkshire Police have now released a new update.
The force said one lane had been reopened following the crash.
However, significant delays are expected in the area.
The force tweeted: "***INCIDENT M62 JUNCTION 31 WEST*** Please be aware there is an incident on the M62.
"Lane 3 is now open.
"Lane 1 and 2 are likely to be closed for some considerable time.
"There may be some delays and we thank the public for their patience whilst we deal with this incident."
Highways England earlier said: "The M62 is closed westbound J31-J30 due to a collision.
"Emergency Services, including West Yorkshire Police are in attendance. An Air Ambulance has left scene.
"Delays are likely on the approach to this closure, with additional journey times also expected on diversion routes.
"Further incident information is available from Highways England by visiting our www.trafficengland.com website and travel apps, or via our @HighwaysYORKS regional Twitter feed. Our 24/7 Customer Contact Centre is also available to provide up to the minute information on 03001235000."